melas syndrome in two iranian children

Authors

m ghofrani from the dept. of child neurology, mofid children s hospital, shahid beheshti university of medical sciences, tehran

gr zamani the department of child neurology, ahwaz university of medical sciences, ahwaz, i.r: iran.

abstract

melas syndrome is a mitochondrial disorder with progressive nature, because adequate treatment is not available. diagnosis of this mitochondrial disorder depends initially on clinical suspicion, which is strengthened by additional metabolic evidence of impaired oxidative metabolism such as high serum or c.s.f. lactate levels and confirmed by demonstration of mitochondrial abnormalities-in muscle biopsy. here we present the clinical course and management of two children with melas syndrome who exhibited progressive neurologic deterioration.

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Journal title:
medical journal of islamic republic of iran

جلد ۱۴، شماره ۲، صفحات ۱۸۱-۱۸۴

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